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Bipolar News

December 4, 2004

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New Brain Scan May Diagnose Bipolar Disorder
... 2004 (Chicago) -- Researchers using a special type of imaging that tracks brain chemicals are able to produce a "chemical fingerprint of bipolar disorder," a ...

MRI Detects Bipolar Disorder
Ivanhoe - USA
(Ivanhoe Newswire) -- Patients with bipolar disorder may have a ... Researchers studied 21 bipolar patients between ages 18 and 54 who were not on any medications. ...

Substance Abuse Relapses: Could It Be a Dual Diagnosis? - New York,NY,USA
... Dr. Weiss has investigated what is known as dual diagnosis for many years, focusing largely on substance abuse and bipolar disorder, which is a mood disorder ...

Brent Springford Junior Speaks To WSFA 12 News
WSFA - Montgomery,AL,USA
... He says that he was devastated by the news and that he is full of grief. He admits he has several medical problems including being diagnosed as bipolar. ...

"Black Box" Warning For Antidepressants
Science Daily (press release) - USA
... UCLA-led Study Challenges Bipolar Depression Treatment Guidelines (July 2, 2003) -- A study led by a UCLA Neuropsychiatric Institute researcher challenges ...

Effective treatments for bipolar illness abound
Yuma Sun - Yuma,AZ,USA
... DONOHUE: I am engaged to a man who has bipolar illness. ... RT. ANSWER: People with bipolar illness fluctuate between two mood extremes -- mania and depression. ...


The Palm Beach Post; 12/1/2004

The Palm Beach Post



Magnetic resonance (MR) spectroscopy may prove to be the definitive diagnostic test for bipolar disorder, a serious brain illness characterized by an alternating pattern of extreme emotional highs and lows, according to a study presented this week at the annual meeting of the Radiological Society of North America.

Using MR spectroscopy of the brain, researchers at the Mayo Clinic in Rochester, Minn., identified significant differences between the brain chemistries of people with and without bipolar disorder.

Bipolar disorder is now diagnosed by psychiatrists based on symptoms and family history. Often patients go undiagnosed for years.

"Bipolar disorder is challenging to diagnose because individuals can cover up the symptoms of the illness or may recognize only their depression, not the manic phase of the disorder," says Dr. John D. Port, assistant professor of radiology and consultant at the Mayo Clinic.

"It's also important to be able to distinguish bipolar disorder from major depression because a mistaken diagnosis can result in the wrong therapy and unstable moods for years."

The National Institute of Mental Health says approximately 2.3 million Americans have bipolar disorder.

The preliminary findings indicated that certain metabolite levels differed significantly between the bipolar group and control group in four areas of the brain that control behavior, movement, vision and reading, and sensory information.

Researchers said this is the first study to analyze drug-free bipolar patients using a 3T longbore MR scanner, which has twice the magnetic-field strength of scanners used in recent bipolar disorder studies.

- Carolyn Susman

Copyright Palm Beach Newspapers, Inc., 2004

Eli Lilly Sues to Block Generic Drug Sale

AP Online; 12/3/2004; KEN KUSMER, AP Business Writer

AP Online


Eli Lilly and Co.'s bestselling drug for schizophrenia and bipolar disorder faces a new patent threat.

Indianapolis-based Lilly sued this week seeking to block Barr Pharmaceuticals Inc. from selling a generic version of Zyprexa Zydis in the United States. Zydis, a wafer form of Zyprexa, rapidly dissolves on contact with saliva and resists being spit out by uncooperative patients.

Attorneys for Lilly filed the patent infringement lawsuit in U.S. District Court in Indianapolis on Wednesday.

A broader patent challenge to Zyprexa was tried earlier this year, though no ruling has been issued yet.

"The arguments Barr raises are similar to those raised in the recent Zyprexa trial," Lilly spokeswoman Terra Fox said.

Barr was not among the generic drugmakers whose patent challenges were consolidated and tried in federal court in Indianapolis this year.

The financial stakes are high despite Zyprexa's declining U.S. sales. Last year's U.S. sales totaled $2.63 billion, or more than a fifth of Lilly's worldwide revenues. During the three months ending Sept. 30, U.S. sales were $557.3 million, still strong enough to represent nearly 17 cents of every dollar Lilly took it during the third quarter.

Lilly's patents on Zyprexa, including Zydis, now give it exclusive U.S. rights to the drug until 2011.

Barr officials said annual sales of Zyprexa Zydis came to $233 million for the 12 months ending with September.

The generic drugmakers in the consolidated case are Zenith Goldline Pharmaceuticals, owned by Ivax Corp. of Miami; Dr. Reddy's Laboratories of India; and the U.S. arm of Israeli-based Teva Pharmaceutical Industries.

Barr spokeswoman Carol Cox said the Pomona, N.Y.-based company was challenging only the Zydis patent because it did not want to join such a large group of litigants and because Barr sells other oral, rapidly dissolving medications.

Lilly's Fox said it could seek to have Barr's case consolidated with the others. It also could request a ruling be delayed until Young issues his opinion.

Lilly stock was down 29 cents to $54.50 Friday on the New York Stock exchange.

Copyright 2004, AP News All Rights Reserved

TAPPING EXUBERANCE How joy powers invention

Newsday; 12/3/2004; JAMIE TALAN



How joy powers invention


Science has put considerable effort into studying the
sadder side of human nature, focusing on negative or destructive emotions. Kay
Redfield Jamison is hoping science will look in the other direction - at

"Joy may be less philosophically satisfying than pain," Redfield said. "But
it's just as important - and a lot more fun."

Jamison is a scientist, writer and professor of psychiatry at Johns Hopkins
University School of Medicine in Baltimore who is probably best known for her
work with bipolar illness - and her own struggle with the disorder. She's
co-written a renowned textbook on the illness, another on madness and
creativity, and the 1995 bestselling autobiography "An Unquiet Mind." She
followed with "Night Falls Fast," about suicide and depression

Most recently she's turned her attention to the opposite end of the
emotional spectrum, interviewing such exuberant notables as James Watson, the
Cold Spring Harbor Laboratory chancellor who was awarded the Nobel Prize for
his role in the discovery of DNA's structure. She asked Watson and other
scientists, artists and historians about the inner motor that drives such

"Exuberance flows," Watson told Jamison, a close friend and scientific
colleague. "It is a state of mind which can only be relieved by communicating
the idea."

Her work resulted in "Exuberance: The Passion for Life," published this
year by Alfred Knopf. On Sunday, Jamison will lecture and sign copies of her
book at the laboratory's Dolan DNA Learning Center in Cold Spring Harbor. The
center can be reached at 516-367-8844.

Theorists suspect that as many as one in 10 people are lucky enough to
embrace a temperament built on long-lasting energy and enthusiasm, she said -
people who are "born bold, active and fearless, people who feel intensively

Jamison said that an exuberant temperament creates Nobel Prize-winners like
Watson and renowned physicist Richard Feynman, whom Alan Alda portrayed on
Broadway in "QED." And she suspects that scientists in particular may benefit
from a high dose.

"Science is full of failure, and you need people to bounce back and get
re-enthused," she said. "Exuberance is contagious," and that energy motivates
others to pursue similar ideas.

To understand the chemistry that drives high energy and high mood is to
capture the force behind many great discoveries, she said. "Exuberance is not
recognized for the vital role it plays in discovery, creativity, leadership and
survival itself ... It forces us out into a greater arena of life."

But push exuberance too far, and mad things can happen.

"In their mild forms, exuberant states are intoxicating and adaptive,"
Jamison writes. "But in their extremes, they are pathological," and can drive
people into recklessness and madness.

She suspects that scientists who are developing drugs that enhance mood in
psychiatric disorders are also tinkering with the idea of designing potions
that artificially trigger exuberance - which she said could have a down side.

"You don't want everyone being exuberant or cautious," she said. "You want
a diversity of temperaments, a variety of energies and moods."

Copyright 2004, Newsday Inc.


The Palm Beach Post; 12/2/2004; PAT MOORE, Palm Beach Post Staff Writer

The Palm Beach Post


BYLINE: PAT MOORE, Palm Beach Post Staff Writer

STUART -- Prosecutors will not seek the death penalty for a Palm City man charged with the October crossbow killing of his 79-year-old mother, Assistant State Attorney Nita Denton said Wednesday.

Prosecutors considered a heartfelt letter from the oldest brother of suspect Bruce Neal and potential mental health defenses when deciding not to pursue the death penalty, she said.

"The family is united in the belief that Bruce at his core is a good person and does not deserve to die for his thoughtless action," Scott Neal wrote about his brother in a letter to State Attorney Bruce Colton.

"I know I speak on behalf of my parents (and other family members) when I state that my brother, Bruce, needs medical help and not to be put to death for his sick behavior."

Bruce Neal, who was diagnosed with a bipolar disorder at age 13, told investigators he was angry with his mother and could not stop the mounting "white rage" inside him before he shot his mother in the chest at the home they shared on Pendarvis Court.

Jean Neal, a tiny woman in failing health, staggered to the kitchen and collapsed.

Bruce Neal called 911, but his mother died later that evening at Martin Memorial Medical Center. He is being held without bail in the Martin County jail, charged with first-degree murder.

Scott Neal, who lives in California, told prosecutors he found several notes written by his brother in the Palm City home while planning his mother's funeral.

"They tell a story of one who is troubled and is trying to be normal and attempting to do the right thing," he said. "His notes suggest he had considered suicide but never did he write a word to suggest he considered violence against any other human being."

Defense attorney Richard Kibbey said his client is undergoing examinations by psychiatric experts in preparation for his trial.

"We are intending to fight rigorously on grounds that he did not commit a premeditated murder," he said.

Denton said prosecutors looked at Bruce Neal's criminal history, including an incident more than 23 years ago when he fired a bow from an arrow into a group of people in New Jersey, but no one was injured.

Bruce Neal also served time in prison in New Jersey after he was stopped with a carload of explosives in 1996.

Denton said prosecutors concluded potential mitigating defenses, including Neal's mental condition at the time he shot his mother, weighed heavily on their decision not to pursue the death penalty.

"We have lobbied the state from the inception to do the right thing, and they have," Kibbey said. "It would have been a waste of time and taxpayers money to pursue the death penalty in this case."

Copyright Palm Beach Newspapers, Inc., 2004

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