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What Causes Bipolar Disorder?

Scientists are learning about the possible causes of bipolar disorder through several kinds of studies. Most scientists now agree that there is no single cause for bipolar disorder-rather, many factors act together to produce the illness.

Because bipolar disorder tends to run in families, researchers have been searching for specific genes-the microscopic "building blocks" of DNA inside all cells that influence how the body and mind work and grow-passed down through generations that may increase a person's chance of developing the illness. But genes are not the whole story. Studies of identical twins, who share all the same genes, indicate that both genes and other factors play a role in bipolar disorder. If bipolar disorder were caused entirely by genes, then the identical twin of someone with the illness would always develop the illness, and research has shown that this is not the case. But if one twin has bipolar disorder, the other twin is more likely to develop the illness than is another sibling.7

In addition, findings from gene research suggest that bipolar disorder, like other mental illnesses, does not occur because of a single gene.8 It appears likely that many different genes act together, and in combination with other factors of the person or the person's environment, to cause bipolar disorder. Finding these genes, each of which contributes only a small amount toward the vulnerability to bipolar disorder, has been extremely difficult. But scientists expect that the advanced research tools now being used will lead to these discoveries and to new and better treatments for bipolar disorder.

Brain-imaging studies are helping scientists learn what goes wrong in the brain to produce bipolar disorder and other mental illnesses.9,10 New brain-imaging techniques allow researchers to take pictures of the living brain at work, to examine its structure and activity, without the need for surgery or other invasive procedures. These techniques include magnetic resonance imaging (MRI), positron emission tomography (PET), and functional magnetic resonance imaging (fMRI). There is evidence from imaging studies that the brains of people with bipolar disorder may differ from the brains of healthy individuals. As the differences are more clearly identified and defined through research, scientists will gain a better understanding of the underlying causes of the illness, and eventually may be able to predict which types of treatment will work most effectively.

References

7NIMH Genetics Workgroup. Genetics and mental disorders. NIH Publication No. 98-4268. Rockville, MD: National Institute of Mental Health, 1998.

8Hyman SE. Introduction to the complex genetics of mental disorders. Biological Psychiatry, 1999; 45(5): 518-21.

9Soares JC, Mann JJ. The anatomy of mood disorders-review of structural neuroimaging studies. Biological Psychiatry, 1997; 41(1): 86-106.

10Soares JC, Mann JJ. The functional neuroanatomy of mood disorders. Journal of Psychiatric Research, 1997; 31(4): 393-432.

This article has been provided by the National Institute of Mental Health, 04/09/2004

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Featured Article:

TAKE ACTION!

I received an email from a person the other day. She asked me why so many great successful people, leaders, business people, etc. have Bipolar Disorder. I have long had a theory (but I don't have any kind of study to point to which would prove my theory). Here's what I think, though:

In order for you to start something, whatever it is: open a daycare center, write a book, build a website, go to college, discover the cure for cancer, create world peace – you have to do something really important. Know what it is?

You have to TAKE ACTION!

Click here to read the entire article.

Featured Article:

A Basic Coping Strategy for Survivors of Bipolar Disorder

There are many ways that I’ve tried to cope with having bipolar disorder, as I’m sure you have as well.

One of the most basic ways I’ve discovered as a basic coping strategy to deal with bipolar disorder is the Serenity Prayer:

God, grant me the serenity
To accept the things I cannot change
The courage to change the things I can
And the wisdom to know the difference.

It doesn’t matter whether you are “religious” or not, the prayer still works.

Click here to read the entire article.

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